Authors
Kuznetsov A.
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Degree
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Postgraduate, Moscow Technological University |
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E-mail
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askuznetsov@mitht.ru |
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Location
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Moscow |
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Articles
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Information support of process structuring elastomeric systems control system using the rheometer curvesIn this article from the standpoint of system analysis the questions of creation of an information
management system to support the process of structuring elastomeric systems are observed. It is necessary
to analyze, control and monitor the process of the structuring of elastomers products for the
product with desired properties and characteristics obtaining and defect product obtaining prevention.
Rheometer curves nowadays are widely used for the mixing and structuring process controlling and
monitoring. The functional diagrams of mixing and structuring process are built and also their further
decomposition is carried out. For all given functional diagrams all functional blocks are being discussed,
the specific operation performers of all technological processes are listed. All necessary equipment
for technological operations are named. By example of the products from elastomers manufacture
information models for the processes of mixing and structuring were built. For the structuring process
description there is also a verbal model in text and table forms is also proposed. The expediency
of rheometer curves in the analysis, control and monitoring of the processes of mixing and structuring
is shown. Given information model and functional diagramms are represent the basis of the information
management system of the mixing and structurig processes support.
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Optimization of the management of continuous synthesis of active pharmaceutical ingredients (API)The article discusses the development of information and algorithmic support for a system for optimizing the control of the synthesis of continuous active pharmaceutical ingredients (APIs) by the example of continuous synthesis of diphenhydramine from chlorine/ bromodiphenylmethane on microreactors. The methodological basis of the proposed development is a systematic implementation of the Quality-by-Design (QbD) principle at the stage of development of continuous synthesis of APIs. Information modeling of the synthesis of diphenhydramine in flow-type devices (microreactors) was carried out. The scheme of an intelligent information support system for the synthesis of diphenhydramine (diphenhydramine) has been developed. The developed intelligent system includes a block for the preparation of managerial decisions, which is intended to formulate on-line recommendations to a researcher conducting synthesis of finished dosage forms (SFF). The main task that is solved using this unit is to predict the quality index of the synthesis process and at the same time determine the critical values of the synthesis, which allows the researcher not to go beyond the given limits. The basis of both the prediction model of the quality assessment indicator and the critical parameters of the process are the ideas of regression analysis. An algorithm for constructing multi-feedback regression equations is presented. The constructed regression equations make it possible to formulate the optimization problem at the second stage, for the solution of which one of the modifications of the coordinate search for the optimum was chosen - the Hook - Jeeves algorithm. A generalized block diagram is presented, which reflects in its most general form an algorithm for optimizing research planning in the continuous synthesis of diphenhydramine. Some results of studies of the continuous synthesis of diphenhydramine on the eduFLOSYS microreactor system are considered. Chlorobenzohydrol and bromobenzohydrol were used as starting components. Read more...
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